Asian Journal of Research and Reports in Gastroenterology <p style="text-align: justify;"><strong>Asian Journal of Research and Reports in Gastroenterology</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/AJRRGA/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of&nbsp;‘Gastroenterology’. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> Asian Journal of Research and Reports in Gastroenterology en-US Asian Journal of Research and Reports in Gastroenterology Rapid Onset Peripheral Neuropathy in a Patient with Amoebic Liver Abscess on Metronidazole - A Rare Complication <p><strong>Aim: </strong>We report here a case where the patient developed peripheral neuropathy during a short course of metronidazole treatment at a low cumulative dose which has been rarely reported. This case thus highlights the importance for a treating medical professional to keep in mind that peripheral neuropathy may develop in a patient on metronidazole even on a short duration of it. This peripheral neuropathy is reversible.</p> <p><strong>Presentation of Case: </strong>A 40 year old male patient with no past history of alcohol habit or diabetes was admitted with right side chest pain. Ultrasound and CECT abdomen revealed Amoebic Liver Abscess. He was treated with Metronidazole. After one week of therapy (cumulative dose -16.8 gms) he developed severe burning pain in bilateral lower limbs with Nerve Conduction Velocity (NCV) study confirming mixed neuropathy. His symptoms resolved after stopping Metronidazole.</p> <p><strong>Discussion: </strong>The exact mechanism of Metronidazole induced peripheral neuropathy is unknown. It is believed to be secondary to axonal degeneration. It binds to neuronal RNA and inhibits protein synthesis. This results in axonal degeneration.</p> <p><strong>Conclusion: </strong>Metronidazole is a widely prescribed drug for treatment of amoebic liver abscess. It can cause peripheral neuropathy in patients even on a short course of treatment. Thus it is important to detect this early and discontinue the medication to prevent development of persistent neuropathy.</p> Mohit Gupta Chandan Kumar Ujjwal Kumar Pranay Swarnkar ##submission.copyrightStatement## 2019-06-15 2019-06-15 1 4 Aetiology, Clinical Profiles, Laboratory Profile, Outcome and Prognostic Factors of Pediatric Acute Liver Failure: Experience at a Tertiary Hospital of Bangladesh <p><strong>Introduction: </strong>Acute liver failure is one of the common causes of death in pediatric gastroenterology and hepatology department. Outcome is different according to aetiology.</p> <p><strong>Objective: </strong>To observe the aetiology, outcome and prognostic factors of pediatric acute liver failure.</p> <p><strong>Methods:</strong> Consecutive 62 children aged 2 to 16 years of age who were diagnosed as acute liver failure from November 2015 to April 2018 were included in this study. All the clinical profiles, laboratory data and outcome were recorded in a preformed data sheet. Data were analysed by SPSS for Windows version 20.</p> <p><strong>Results:</strong> Mean age was 8.5 years. Thirty-nine (62.9%) patients were between 5-10 years of age. Male were 53%. We made a diagnosis of 39 (63%) patients as Wilson disease alone; Another 3 Wilson disease acute liver failure patients had concomitant with HAV, HEV or HSV in each one. HAV only was responsible for 17 patients and HEV for 1. One patient was Haemophagocytic lymphohistiocytosis and etiology could not be identified in 1 patient. The overall death in study population was 48% (30). Twenty-four (57%) of 42 acute liver failure patients due to Wilson disease had died. Five (29%) of 17 patients due to HAV infection and 1 patient with HLH died. Ascites, high total bilirubin, high INR and etiology like Wilson disease were the worse prognostic factors for outcome of acute liver failure in children.</p> <p><strong>Conclusion:</strong> Wilson disease was the most common aetiology of acute liver failure in children in this study. Early diagnosis is essential as outcome was worse. Majority of viral etiology improved with supportive care.</p> Afsana Yasmin A. S. M. Bazlul Karim Md. Rukunuzzaman Shashi Bhushan Thakur Luthfun Nahar Md. Benzamin ##submission.copyrightStatement## 2019-05-11 2019-05-11 1 8