Asian Journal of Research and Reports in Gastroenterology https://journalajrrga.com/index.php/AJRRGA <p style="text-align: justify;"><strong>Asian Journal of Research and Reports in Gastroenterology</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/AJRRGA/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of&nbsp;‘Gastroenterology’. By not excluding papers based on novelty, this journal facilitates the research and wishes to publish papers as long as they are technically correct and scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled, OPEN peer-reviewed, open-access INTERNATIONAL journal.</p> en-US contact@journalajrrga.com (Asian Journal of Research and Reports in Gastroenterology) contact@journalajrrga.com (Asian Journal of Research and Reports in Gastroenterology) Fri, 26 Aug 2022 00:00:00 +0000 OJS 3.1.1.4 http://blogs.law.harvard.edu/tech/rss 60 Secondary Hemosiderosis in a Case of Alcoholic Liver Disease: Getting to the Root Cause https://journalajrrga.com/index.php/AJRRGA/article/view/80 <p>Hemosiderosis stands for the presence of&nbsp;demonstrable iron in tissues, mainly in&nbsp;parenchymal organs like liver and pancreas. Hemosiderosis in chronic liver disease often remains undiagnosed and the association between alcohol consumption and hemosiderosis may not be of common knowledge among physicians. We present the autopsy findings of a patient diagnosed with alcoholic liver disease who remained undiagnosed for secondary hemosiderosis until his demise. Pathogenesis of secondary hemosiderosis in alcoholic liver disease is discussed.</p> Deepti Mutreja, Jyoti Prasad Saikia, Havarala Keerthana, Sigin George ##submission.copyrightStatement## https://journalajrrga.com/index.php/AJRRGA/article/view/80 Tue, 30 Aug 2022 00:00:00 +0000 A Rare Cause of Dysphagia: Esophageal Papillomatosis Complicated by Squamous Cell Carcinoma https://journalajrrga.com/index.php/AJRRGA/article/view/81 <p>Esophageal papillomatosis is a fairly rare illness that is thought to have a benign clinical course. Recent findings highlight the possibility of a malignancy emerging in connection with esophageal squamous papillomatosis. A case of esophageal papillomatosis is documented, which was worsened by the development of esophageal invasive squamous cell carcinoma following numerous nondiagnostic endoscopic biopsies. In addition, the patient developed squamous cell carcinoma in the oral cavity. Extensive esophageal papillomatosis and recurrent dysphagia symptoms should prompt an examination into an underlying malignancy.</p> H. Mahtal, S. Nacer, S. Abadi, Fz. Elghaoussi, M. Tahiri, F. Haddad, W. Hliwa, A. Bellabah, W. Badre, E. M. Choukri, K. El Hattabi, Fz. Bensardi, A. El Bakouri, M. Bouali, A. Fadil ##submission.copyrightStatement## https://journalajrrga.com/index.php/AJRRGA/article/view/81 Wed, 02 Nov 2022 00:00:00 +0000 Alleviation of Acetic Acid-Induced Ulcerative Colitis in Rat Model by Vernonia amygdalina (Asteraceae) Leaf Extract https://journalajrrga.com/index.php/AJRRGA/article/view/79 <p><strong>Background:</strong> Ulcerative colitis (UC) is a category of chronic inflammatory intestinal disease of unknown origin. Some medicinal plants have been used as therapeutic targets for UC, however, there is a paucity of information on the use of <em>Vernonia amygdalina</em> leaves.</p> <p><strong>Aim: </strong>The present study aimed to investigate the protective effects of aqueous extract of <em>V. amygdalina</em> leaves (<em>AEVA</em>) on experimental rat models of ulcerative colitis.</p> <p><strong>Place and Duration of Study:</strong> Department of Medical Laboratory Sciences and Animal House, College of Medicine, University of Nigeria, Enugu Campus, between September 2016 and November 2018.</p> <p><strong>Methodology:</strong> Twenty-four rats equally divided into six groups were used for the study. A control group received only drinking water while UC was induced by transrectal infusion of 1 ml of 4% acetic acid into rats in 5 groups. UC-model rats were given no further treatment whereas the other four treatment groups received a single oral daily dose of sulfasalazine (SSZ, 225 mg/kg), 50, 100, and 200 mg/kg body weight (b.wt.) of <em>AEVA</em> for seven days. The rats were, thereafter, weighed and sacrificed under chloroform anesthesia. The distal colon of each rat was excised, weighed, and examined both macroscopically and microscopically. Histopathological grading was conducted to determine the extent of the injury.</p> <p><strong>Results:</strong> Results revealed severe inflammatory cellular infiltration, mucosal erosion, and ulceration in the UC-model rats. However, a dose-dependent reduction in the colonic lesions was observed following treatment with <em>AEVA</em> and the most potent dose was 200 mg/kg b.wt.</p> <p><strong>Conclusion:</strong> The present study has indicated that the aqueous extract of <em>Vernonia amygdalina </em>leaves mitigates AA-induced ulcerative colitis and hence may be offered as a potential therapeutic agent.</p> N. C. Azubuike, F. U. Nzenwa ##submission.copyrightStatement## https://journalajrrga.com/index.php/AJRRGA/article/view/79 Fri, 26 Aug 2022 00:00:00 +0000 Distribution of Chronic Gastropathies and Associated Factors with the Presence of Anti-Gastric Parietal Cell Antibodies in a Cameroonian Population https://journalajrrga.com/index.php/AJRRGA/article/view/82 <p><strong>Background and Aim: </strong>Data on autoimmunity is and remains scarce in Central Africa due to the orientation of most research programs on infectious diseases. As of now, the diagnosis of autoimmune diseases in Cameroon is very limited. Anti-gastric parietal cell antibodies (AGPCA) lead to destruction of the gastric wall resulting in atrophy. The objective of this study was to determine the prevalence of AGPCA and their association with socio-demographic factors in patients suffering from chronic gastropathies.&nbsp;</p> <p><strong>Methodology:</strong> This was a cross- sectional study carried out from March to October 2020, in two hospitals in the city of Douala. The type of gastropathy was determined by endoscopy and autoantibodies were tested by Indirect Immunofluorescence at Centre Pasteur Cameroon. The kit used was Euroimmum Lot F 211117DB, and a fluorescence microscope of the mark Leica DM 1000 was used to observe the reactions. Data was analysed using SPSS 25.0, and a P value of 0.05 was considered as being significant.</p> <p><strong>Results: </strong>120 patients were enrolled in this study and constituted 57 (47.5%) men and 63 (52.5%) women with a male to female sex ratio of 0.9. The prevalence of AGPCA was 10.8%. The age of the patients who were tested positive to anti-gastric parietal cell antibodies ranged from 21 to 87 years with P value 0.003, and constituted 6 men and 7 women with P value 0.918 and OR 1.063(0.335 – 3.371). The most represented type of gastropathy was gastritis in 6 (46.2%) patients, P value 0.032 with occupation factor. The adjusted Odds Ratio (AOR) was 1.414 (0.798 - 2.507) and P value 0.236 for the risk factor age.</p> <p><strong>Conclusion:</strong> The overall prevalence of ACPG in our study was 10.8%. In bivariate analysis, we found associations with age, occupation and&nbsp; type of gastropathy. Although very often present in elderly people, the results obtained in this study are in favor of a more or less homogeneous distribution in the population.</p> Tsanga Touna Joseph Wilfried, Bertille Elodie Eyebe Edinga, Sepo David, Adiogo Dieudonné ##submission.copyrightStatement## https://journalajrrga.com/index.php/AJRRGA/article/view/82 Mon, 21 Nov 2022 00:00:00 +0000