A Fatal Case of Autoimmune Hepatitis–primary Biliary Cholangitis Overlap Syndrome in Lomé University Hospital, Togo
Laté Mawuli Lawson-Ananissoh *
Gastroenterology Department, Campus Teaching Hospital, Lome, Togo.
Affissou Kola Karimou
Gastroenterology Department, Campus Teaching Hospital, Lome, Togo.
Mawunyo Henoc Gbolou
Gastroenterology Department, Campus Teaching Hospital, Lome, Togo.
Lidawu Roland-Moise Kogoe
Gastroenterology Department, Campus Teaching Hospital, Lome, Togo.
Yendoukoa Yves Kanake
Gastroenterology Department, Campus Teaching Hospital, Lome, Togo.
Debehoma Venceslas Redah
Gastroenterology Department, Campus Teaching Hospital, Lome, Togo.
Aklesso Bagny
Gastroenterology Department, Campus Teaching Hospital, Lome, Togo.
*Author to whom correspondence should be addressed.
Abstract
Autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC) are two chronic liver diseases whose respective diagnoses are based on well-defined clinical, biological, immunological, and histological criteria. Sometimes, in the same individual, the characteristic signs of these two conditions overlap, either simultaneously in most cases or consecutively in rare cases, resulting in an overlap syndrome. We report a case of chronic cholestasis in a 38-year-old female patient living in Togo, evoking a probable PBC-AIH overlap syndrome complicated by cirrhosis classified as CHILD-PUGH C 12, decompensated in the ictero-edemato-ascitic mode, plus grade 3 esophageal varices with red signs. In the absence of liver transplantation, the evolution was towards death in the context of hepatic encephalopathy.
Keywords: Cholestasis, autoimmune hepatitis, primary biliary cholangitis, overlap syndrome, Togo