Atypical Manifestation of IgG-4 Related Disease as Space Occupying Lesion Mimicking Hepatocellular Carcinoma in a Renal Transplant Recipient

Kiran Bajaj

Department of Gastroenterology and Hepatology, Sindh Institute of Urology and Transplantation, Pakistan.

Raja Taha Yaseen Khan *

Department of Gastroenterology and Hepatology, Sindh Institute of Urology and Transplantation, Pakistan.

Shoaib Ahmed Khan

Department of Gastroenterology and Hepatology, Sindh Institute of Urology and Transplantation, Pakistan.

Zain Majid

Department of Gastroenterology and Hepatology, Sindh Institute of Urology and Transplantation, Pakistan.

Nasir Mehmood

Department of Gastroenterology and Hepatology, Sindh Institute of Urology and Transplantation, Pakistan.

Muhammad Ali Khalid

Department of Gastroenterology and Hepatology, Sindh Institute of Urology and Transplantation, Pakistan.

Abbas Ali Tasneem

Department of Gastroenterology and Hepatology, Sindh Institute of Urology and Transplantation, Pakistan.

Syed Mudassir Laeeq

Department of Gastroenterology and Hepatology, Sindh Institute of Urology and Transplantation, Pakistan.

Nasir Hasan Luck

Department of Gastroenterology and Hepatology, Sindh Institute of Urology and Transplantation, Pakistan.

*Author to whom correspondence should be addressed.


Abstract

IgG4-related disease (IgG4-RD) is a multisystem fibro-inflammatory condition mostly prevalent in older males. The cornerstone for the treatment of IgG4 related disease is Corticosteroids.It rarely affects immunosuppressive population such as solid organ transplantation. Here we present to you a case of a young lady with a history of renal transplantation evaluated for symptoms of abdominal pain and weight loss and was diagnosed as a case of IgG4 related liver disease on the basis of liver lesion biopsy.

Keywords: Immunosuppressants, hepatocellular carcinoma, fibroinflammation, weight loss, abdominal pain


How to Cite

Bajaj , Kiran, Raja Taha Yaseen Khan, Shoaib Ahmed Khan, Zain Majid, Nasir Mehmood, Muhammad Ali Khalid, Abbas Ali Tasneem, Syed Mudassir Laeeq, and Nasir Hasan Luck. 2023. “Atypical Manifestation of IgG-4 Related Disease As Space Occupying Lesion Mimicking Hepatocellular Carcinoma in a Renal Transplant Recipient”. Asian Journal of Research and Reports in Gastroenterology 6 (1):21-24. https://journalajrrga.com/index.php/AJRRGA/article/view/94.

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References

Deshpande V, Zen Y, Chan JKC, et al. Consensus statement on the pathology of IgG4-related disease. Mod Pathol. 2012;25(9):1181-92.

Kamisawa T, Funata N, Hayashi Y, Eishi Y, Koike M, Tsuruta K, et al. A new clinicopathological entity of IgG4-related autoimmune disease. J Gastroenterol. 2003;38((10)):982-4.

Della-Torre E, Lanzillotta M, Doglioni C. Immunologyof IgG4-related disease. Clin Exp Immunol. 2015;181(2):191-206.

Chuang CH, Chien YS, Cheng YT, Chen YT, Hu TH, Hsieh H. Hepatocellular carcinoma in renal transplant recipients. InTransplantation Proc. 2008;40(7):2392-2394. DOI: 10.1016/j.transproceed.2008.06.026, PMID 18790244.

Bruix J, Sherman M. Management of hepatocellular carcinoma: An update. Hepatol. 2011;53(3):1020.

Kamisawa T, Funata N, Hayashi Y, et al. A new clinicopathological entity of IgG4-related autoimmune disease. J Gastroenterol. 2003;38(10):982-4.

Yan FH, Zhou KR, Jiang YP, Shi WB. Inflammatory pseudotumor of the liver: 13 cases of MRI findings. World J Gastroenterol. 2001;7(3):422-4. DOI: 10.3748/wjg.v7.i3.422, PMID 11819804.

Jandee S, Boonsri P. Atypical manifestations of IgG4-related disease as multiple liver abscesses with subcapsular tracts and migratory pulmonary nodules mimicking parasitic infection. Case Rep Gastroenterol. 2020;14(3):458-66.

DOI: 10.1159/000509501, PMID 33173461.

Kamisawa T, Shimosegawa T, Okazaki K, Nishino T, Watanabe H, Kanno A, et al. Standard steroid treatment for autoimmune pancreatitis. Gut. 2009;58(11):1504-7. DOI: 10.1136/gut.2008.172908, PMID 19398440.

Yan FH, Zhou KR, Jiang YP, Shi WB. Inflammatory pseudotumor of the liver: 13 cases of MRI findings. World J Gastroenterol. 2001;7(3):422-4. DOI: 10.3748/wjg.v7.i3.422, PMID 11819804.

Kim AJ, Ro H, Chang JH, Jung JY, Chung WK, Park YH, et al. Suspected frequent relapsing IgG4-related lung disease in kidney transplant patient: A case report. Transplant Proc. 2018;50(8):2572-4.

DOI: 10.1016/j.transproceed.2018.02.197, PMID 30316401.